Ketogenic diet as a metabolic therapy for bipolar disorder: Clinical developments
نویسندگان
چکیده
Key underlying metabolic pathologies are thought to play a role in bipolar disorder (BD), including dysfunctions energy metabolism. This review highlights mechanisms of BD and potential therapeutic effects low carbohydrate ketogenic diet (KD) on mood symptoms. Based its robust effectiveness treating epilepsy, the KD has garnered recent interest application for disorders as it may imitate pharmacological stabilizers, commonly prescribed agents treatment both amongst other stabilizing neural networks brain. A literature was conducted current clinical developments KD. Recent findings support idea that have roots dysfunction: cerebral glucose hypometabolism, oxidative stress, well mitochondrial neurotransmitter dysfunction. provides alternative fuel brain is believed contain beneficial neuroprotective effects, network stabilization inflammation reduction. Several insulin resistance, weight, lipid composition been shown. Limited case studies reported date. Preliminary data further testing tool repairing metabolism illness. Additionally, repair deficits often seen BD. Further research trials needed evaluate efficacy supplemental or co-treatment illness an open-label pilot trial currently underway at Stanford.
منابع مشابه
efficacy of the ketogenic diet as a therapy for intractable epilepsy in children
objective to determine the role of ketogenic diet in the treatment of intractable epilepsy in children. materials & methods sixty six consecutive children (1-16 years old) with intractable epilepsy whose seizure were not neurodegenerative nor febrile in origin were recruited. they received the ketogenic diet and we evaluated its effect on seizure frequency for 3 months. all these children had m...
متن کاملA pilot study of the Spanish Ketogenic Mediterranean Diet: an effective therapy for the metabolic syndrome.
The "Spanish Ketogenic Mediterranean Diet" (SKMD) has been shown to promote potential therapeutic properties for the metabolic syndrome. The purpose of this study was to evaluate the potential therapeutic properties under free-living conditions of the SKMD in patients with metabolic syndrome (following the International Diabetes Federation consensus guidelines) over a 12-week period. A prospect...
متن کاملLurasidone as a potential therapy for bipolar disorder
Lurasidone is a benzisothiazol derivative and an atypical antipsychotic approved by the US Food and Drug Administration for the acute treatment of adults with schizophrenia (October 2010) and bipolar 1 depression (June 2013). Lurasidone has a strong antagonistic property at the D2, serotonin (5-HT)2A, and 5-HT7 receptors, and partial agonistic property at the 5-HT1A receptor. Lurasidone also ha...
متن کاملKetogenic diet therapy for epilepsy during pregnancy: A case series
PURPOSE Evaluation of ketogenic diet (KD) therapies for seizure control during pregnancy when safety and appropriate management become considerations. Until now, no information has been available on seizure reduction and human pregnancy related outcomes in women treated with KD therapies. METHOD We describe two cases of pregnant women with epilepsy treated with KD therapy either as monotherap...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of affective disorders reports
سال: 2023
ISSN: ['2666-9153']
DOI: https://doi.org/10.1016/j.jadr.2022.100457